If the following problems occur, check the original and the status of the scanner.
Originals jam frequently
Paper feed errors occur frequently
Document protection issues occur frequently
For originals with folds or that are curled, flatten the original before loading.
When loading originals with a mixture of different sizes, load the originals with the side to be scanned facing up and in descending order of paper size with the widest at the back and the narrowest at the center of the input tray. Next, slide the edge guides to align them with the widest originals.

Placing a Mixture of Originals at Different Sizes
If the problem is not solved, try scanning the originals at each size separately, or scan the originals one by one. Align the edge guides to the width of the originals each time you load them.
You can use the following methods to scan the originals multiple times separately and then save them to one file.
When you are using Epson Scan 2, select Add or edit pages after scanning checkbox, and then scan the original. You can add different originals or edit (rotate, move, and delete) the scanned pages after scanning. See the Epson Scan 2 help for details.
When using Document Capture Pro, you can add originals for scanning or edit scanned pages (rotate, move, or delete) on the Edit Scanned Results screen. Alternatively, you can quickly perform additional scans without changing the settings by selecting Show the confirmation dialog after scanning on the Scan Settings screen.
See the Document Capture Pro help for details.
After scanning, remove the original from the output tray.