After using the scanner for a while, paper and room dust on the roller or the glass part inside the scanner may cause paper feed or scanned image quality problems. Clean the inside of the scanner every 5,000 scans.
If a surface is stained with a hard-to-remove material, use a genuine Epson cleaning kit to remove the stains. Use a small amount of cleaner on the cleaning cloth to remove the stains.
Never use alcohol, thinner, or any corrosive solvent to clean the scanner. Deformation or discoloration may occur.
Never spray any liquid or lubricant on the scanner. Damage to equipment or circuits may cause abnormal operations.
Never open the scanner case.
Press the 
button to turn off the scanner.
Unplug the AC adapter from the scanner.
Pull the lever and open the scanner cover.
Wipe off any stains on the plastic roller (4 locations) and glass surface at the bottom inside of the scanner cover. Wipe with a soft, lint-free cloth dampened with a small amount of dedicated cleaner or water.
Do not place too much force on the glass surface.
Do not use a brush or a hard tool. Any scratches on the glass may affect the scan quality.
Do not spray cleaner directly onto the glass surface.
Wipe off any stains on the sensors with a cotton swab.
Do not use liquid such as a cleaner on a cotton swab.
Open the cover, and then remove the separation roller.
Wipe the separation roller. Wipe with a soft, lint-free cloth dampened with a small amount of dedicated cleaner or water.
Use only a genuine Epson cleaning kit or a soft, moist cloth to clean the roller. Using a dry cloth may damage the surface of the roller.
Open the cover, and then remove the pickup roller.
Wipe the pickup roller. Wipe with a soft, lint-free cloth dampened with a small amount of dedicated cleaner or water.
Use only a genuine Epson cleaning kit or a soft, moist cloth to clean the roller. Using a dry cloth may damage the surface of the roller.
Close the scanner cover.
Plug in the AC adapter, and then turn on the scanner.
Select Scanner Maintenance from the home screen.
On the Scanner Maintenance screen, select Roller Cleaning.
Pull the lever to open the scanner cover.
The scanner enters roller cleaning mode.
Slowly rotate the rollers at the bottom by tapping anywhere on the LCD. Wipe the surface of the rollers using a genuine Epson cleaning kit or a soft cloth dampened with water. Repeat this until the rollers are clean.
Be careful not to get your hands or hair caught in the mechanism when operating the roller. This could cause an injury.
Close the scanner cover.
The scanner exits roller cleaning mode.