Check the following if you have tried all of the solutions and have not solved the problem.
Solutions
Use Epson Scan 2 Utility to initialize the settings for the scanner software.
Epson Scan 2 Utility is an application supplied with the scanner software.
Start the Epson Scan 2 Utility.
Select the Other tab.
Click Reset.
If initialization does not solve the problem, uninstall and re-install the scanner software.