If you are scanning with the ADF, check that the document cover and ADF cover are closed.
Connect the USB cable securely to the printer and the computer. If you are using a USB hub, try to connect the printer directly to the computer.
If you scan at a high resolution over a network, a communication error may occur. Lower the resolution.
Make sure that the correct printer (scanner) is selected on Epson Scan 2.
In Windows, make sure the printer (scanner) is displayed in Scanner and Camera. The printer (scanner) should be displayed as "EPSON XXXXX (printer name)". If the printer (scanner) is not displayed, uninstall and then re-install Epson Scan 2. See the following to access Scanner and Camera.
Windows 10
Click on the start button, and then select Windows System > Control Panel, enter "Scanner and Camera" in the search charm, click View scanners and cameras, and then check if the printer is displayed.
Windows 8.1/Windows 8/Windows Server 2012 R2/Windows Server 2012
Select Desktop > Settings > Control Panel, enter "Scanner and Camera" in the search charm, click Show Scanner and Camera, and then check if the printer is displayed.
Windows 7/Windows Server 2008 R2
Click the start button and select Control Panel, enter "Scanner and Camera" in the search charm, click View scanners and cameras, and then check if the printer is displayed.
Windows Vista/Windows Server 2008
Click the start button, select Control Panel > Hardware and Sound > Scanners and Cameras, and then check if the printer is displayed.
Windows XP/Windows Server 2003 R2/Windows Server 2003
Click the start button, select Control Panel > Printers and Other Hardware > Scanner and Cameras, and then check if the printer is displayed.